Genetic Risk Score Predicts Late-Life Cognitive Impairment

نویسندگان

  • Mariegold E. Wollam
  • Andrea M. Weinstein
  • Judith A. Saxton
  • Lisa Morrow
  • Beth Snitz
  • Nicole R. Fowler
  • Barbara L. Suever Erickson
  • Kathryn A. Roecklein
  • Kirk I. Erickson
چکیده

Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia.

The baby boom generation is approaching the age of greatest risk for cognitive impairment and dementia. There is growing interest in strategies to modify the environment in midlife to increase the probability of maintaining cognitive health in late life. Several potentially modifiable risk factors have been studied in relation to cognitive impairment and dementia in late life, but methodologica...

متن کامل

Association of lifetime intellectual enrichment with cognitive decline in the older population.

IMPORTANCE Intellectual lifestyle enrichment throughout life is increasingly viewed as a protective strategy against commonly observed cognitive decline in the older population. OBJECTIVES To investigate the association of lifetime intellectual enrichment with baseline cognitive performance and rate of cognitive decline in an older population without dementia and to estimate the years of prot...

متن کامل

Time away from work predicts later cognitive function: differences by activity during leave.

PURPOSE We sought to examine how different activities performed during employment gaps are associated with later cognitive function and change. METHODS Five cognitive measures were used to indicate cognitive impairment of 18,259 respondents to the Survey of Health, Ageing, and Retirement in Europe (ages 50-73) in 2004/5 or 2006/7. Using complete employment histories, employment gaps of ≥6 mon...

متن کامل

The prevalence of Cognitive Impairment in Patients with Type II Diabetes and its Relationship with Quality of Life, Self-Management Profiles, and HbA1c

Objective: Diabetes mellitus (DM) is a common metabolic. One of the unknown complications of DM is cognitive disorders. Different types of cognitive impairment caused by DM may affect the quality of life, self-management of diabetes, and glycosylated hemoglobin. This study aimed to determine the prevalence of cognitive impairment and its relationship with glycosylated hemoglobin (HbA1c), diabet...

متن کامل

Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study

BACKGROUND Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression. METHODS 130 individuals aged ≥ 65 years ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2015  شماره 

صفحات  -

تاریخ انتشار 2015